Acquired mutation: A mutation (a genetic change) acquired by a somatic cell after conception. Acquired mutations occur in somatic cells, not germ cells , and so cannot be transmitted to the children. However, acquired mutations are transmitted to all cells descended from the mutant cell, giving rise to a clone (colony) of cells marked by the mutation. Some acquired mutations are involved in the development of cancer. Also known as an acquired genetic mutation, somatic mutation , or somatic cell mutation.

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