Adiponectin: A protein hormone produced and secreted exclusively by adipocytes (fat cells) that regulates the metabolism of lipids and glucose . Adiponectin influences the body's response to insulin . Adiponectin also has antiinflammatory effects on the cells lining the walls of blood vessels.

High blood levels of adiponectin are associated with a reduced risk of heart attack . Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack).

Adipocytes produce and secrete a number of proteins, including leptin , adipsin, properdin, and tumor necrosis factor ( TNF ). An adipose tissue-specific factor was isolated and termed APM1 (AdiPose Most abundant gene transcript 1). The protein product of APM1 is adiponectin. The APM1 gene maps to chromosome 3q27.

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