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Anion gap: A measurement of the interval between the sum of "routinely measured" cations minus the sum of the "routinely measured" anions in the blood. The anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium , K+ is potassium , Cl- is chloride , and HCO3- is bicarbonate .

The anion gap can be normal, high, or low. A high anion gap indicated metabolic acidosis , the increased acidity of the blood due to metabolic processes. A low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins , as in multiple myeloma .


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