Appendicitis : Inflammation of the appendix. Appendicitis usually also involves infection of the appendix, the finger-like projection from the first part of the colon (the large intestine).

Appendicitis often causes fever , loss of appetite, and right lower quadrant abdominal pain most marked at what is called McBurney's point.

The most exquisitely tender area of the abdomen in the early stage of appendicitis, this point is named after the New York surgeon Charles McBurney (1845-1913), the leading authority in his day on appendicitis. In 1889, McBurney showed that incipient appendicitis could be detected by applying pressure to a particular spot in the right lower abdomen, a point he called the "seat of greatest pain," which corresponds to the normal location of the base of the appendix.

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