Aromatase: An enzyme involved in the production of estrogen that acts by catalyzing the conversion of testosterone (an androgen) to estradiol (an estrogen). Aromatase is located in estrogen-producing cells in the adrenal glands, ovaries, placenta, testicles, adipose (fat) tissue, and brain.

The growth of some breast cancers is promoted by estrogens . For example, the drug letrozole (brand name: Femara) is an antiestrogen sometimes used to treat such estrogen-dependent tumors. The drug acts by inhibiting the enzyme aromatase which lowers the level of the estrogen, estradiol.

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