Bisphosphonate: A class of drugs used to strengthen bone. Bone is in a constant state of remodeling, whereby new bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts . Bisphosphonates inhibit bone removal ( resorption ) by the osteoclasts. Bisphosphonates are used to treat osteoporosis and the bone pain from diseases such as metastatic breast cancer , multiple myeloma , and Paget's disease . The bisphosphonates include Fosamax (alendronate) and Aredia (pamidronate).

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