Breast cancer gene BRCA2: A gene that normally acts to restrain the growth of cells in the breast but which, when mutated, may predispose to breast cancer.

The first breast cancer genes identified were BRCA1 and BRCA2. Mutations of BRCA1 and BRCA2 account for about half of all cases of inherited breast cancer. These tumors tend to occur in young women. BRCA1 and BRCA2 are usually not involved in breast cancer that is not hereditary.

BRCA2 mutations have also been discovered to be responsible for a significant fraction of early-onset prostate cancer, even in families without a history of breast and ovarian cancer.

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