Colorectal cancer: Cancer of the colon and rectum. A malignant tumor arising from the inner wall of the large intestine. Risk factors include heredity, colon polyps , and long standing ulcerative colitis . Most colorectal cancers develop from polyps. Removal of colon polyps can prevent colorectal cancer. Since colon polyps and early cancer can have no symptoms, regular screening is important. Diagnosis can be made by barium enema or by colonoscopy with biopsy confirmation of cancer tissue. Surgery is the most common treatment for colorectal cancer.

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