Cox-1 inhibitor: An agent that inhibits the action of the enzyme cox-1 (cyclooxygenase-1). The common anti-inflammatory drugs such as aspirin, ibuprofen , and naproxen block the action of both cox-1 and cox-2 . Cox-1 inhibitors can reduce inflammation , but they may also decrease the natural protective mucus lining of the stomach. Therefore, these medications can cause stomach upset, intestinal bleeding, and ulcers. In some cases, using a buffered form of a cox-1 inhibitor can eliminate or reduce these adverse effects.

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