Cox-2 inhibitor: A type of drug that selectively blocks the enzyme cox-2 (cyclooxygenase-2). Blocking this enzyme impedes the production of the chemical messengers called prostaglandins that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors may not pose as great a risk of injuring the stomach or intestines as cox-1 inhibitors. Cox-2 inhibitors now on the market include celecoxib (brand name: Celebrex) and rofecoxib (brand name: Vioxx).

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