Cryoglobulin: An abnormal blood protein that has the unusual properties of precipitating from the blood serum when it is chilled (hence the "cryo-") and redissolving when it is rewarmed. Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000.

Cryoglobulins can cause problems by causing the blood to be abnormally "thick" which increases the risk of blood clots forming in the brain ( stroke ), eyes, and heart. Cryoglobulins are also associated with inflammation of blood vessels ( vasculitis ) which increases the risk of blockage of arteries.

Cryoglobulins are a key part of a condition called essential mixed cryoglobulinemia . Cryoglobulins can also accompany diseases such as multiple myeloma , dermatomyositis , and lymphoma . Sometimes small amounts of cryoglobulin are discovered by accident in the lab in a serum sample from someone with no apparent symptoms.

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