Epidermolysis bullosa acquisita: A rare autoimmune skin disease with blisters. In epidermolysis bullosa acquisita (EBA) the body attacks its own anchoring fibrils with antibodies. The anchoring filaments (thread-like fibers) are structures that anchor the epidermis to the underlying basement membrane. The destruction of the anchoring fibrils leads to tissue separation and blistering in the upper part of the basement membrane.In some cases, EBA has occurred following drug therapy for another condition; in most cases, the cause is unknown. See also: Epidermolysis bullosa .

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