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Essential mixed cryoglobulinemia: A condition in which cryoglobulin proteins which are a mixture of various antibody types form for unknown ( essential ) reasons.

Cryoglobulins are abnormal blood proteins that, by definition, have the unusual properties of precipitating from the blood serum when it is chilled (hence the "cryo-") and redissolving upon rewarming. Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000.

Cryoglobulins can cause problems by causing:

  • The blood to be abnormally "thick" which increases the risk of blood clots forming in the brain ( stroke ), eyes, and heart.
  • Inflammation of blood vessels ( vasculitis ) which increases the risk of blockage of arteries.

Essential mixed cryoglobulinemia is characterized by joint pains and swelling ( arthritis ), enlargement of the spleen , skin vasculitis with purplish patches, and nerve, kidney and heart disease.

Treatment is with medications which reduce inflammation and suppress the immune system. Plasmapheresis , in which the blood's serum is replaced with saline (salt water solution), may be done in severe cases.

Cryoglobulinemia can also accompany another disease such as multiple myeloma , dermatomyositis , or lymphoma .

Sometimes, small amounts of cryoglobulins are discovered by accident in the lab in a serum sample from someone with no apparent symptoms.


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