Estrogen/progestin therapy: Abbreviated EPT. A combination of the hormones estrogen and progestin . Taken by women, the estrogen in the EPT relieves such symptoms of menopause as hot flashes , night sweats , sleeplessness, and vaginal dryness. When taken alone, however, estrogen also increases the risk for cancer of the uterine lining , or endometrium . Combining estrogen with progestin virtually eliminates the risk of endometrial cancer. EPT is a form of hormone replacement therapy ( HRT ).

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