Fatal familial insomnia: Abbreviated FFI. An hereditary prion disease characterized by disrupted sleep ( insomnia ), motor abnormalities ( myoclonus , ataxia , dysarthria , dysphagia , and pyramidal signs), and hyperactivation of the autonomic nervous system . Due to a missense mutation at codon 178 of the prion protein gene on chromosome 20. A sporadic form of fatal insomnia is also known.

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