Herpes: A family of viruses. Herpes also refers to infection with one of the human herpesviruses, especially herpes simplex types 1 and 2.

Herpes simplex type 1, also known as human herpesvirus 1 (HHV-1), causes cold sores and fever blisters in the mouth and around it. Here is a depiction of a typical fever blister on the lip caused by HHV-1:

Herpes simplex type 2, also known as human herpesvirus 1 (HHV-1), causes genital herpes , a sexually transmitted disease ( STD ). Genital herpes is characterized by sores in the genital area.

Both herpes simplex types 1 and 2 are capable of causing systemic disease including encephalitis (infection of the brain) in someone who is immunodeficient .

The treatment of infection with herpes simplex infections is by topical or oral anti-viral medication.

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