Keratitis-ichthyosis-deafness syndrome: An inherited disorder in which affected persons have: - Keratitis -- gradual destruction of the cornea of the eye , sometimes leading to blindness
- Ichthyosis -- localized areas of disfiguring reddish thickened skin ("fish skin")
- Deafness -- at birth
Another characteristic feature is thin or even absent scalp hair. Some patients have developed carcinoma of the tongue while others have subtle abnormalities of the nervous system .
The KID syndrome is inherited as an autosomal dominant trait . The cause of the syndrome is mutation in the connexin-26 gene (which is located on chromosome 13).
The disease is also called the KID syndrome, an acronym for Keratitis-Ichthyosis-Deafness.
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