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Lamin A: Abbreviated LMNA. A gene on chromosome 1 that encodes a protein which is a key component of the membrane surrounding the cell nucleus. Mutations in the LMNA gene are responsible for a number of genetic disorders including:

  • Progeria syndrome ,
  • Emery-Dreifuss muscular dystrophy type 2,
  • Limb girdle muscular dystrophy type 1B,
  • Charcot-Marie-Tooth disorder type 2B1,
  • The Dunnigan type of familial partial lipodystrophy ,
  • Mandibuloacral dysplasia and
  • A familial form of dilated cardiomyopathy .
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