Major depression: A disease with certain characteristic signs and symptoms that interferes with the ability to work, sleep , eat, and enjoy once pleasurable activities.

The characteristic signs and symptoms of major depression include loss of interest in activities that were once interesting or enjoyable, including sex; loss of appetite ( anorexia ) with weight loss or overeating with weight gain; loss of emotional expression (flat affect); a persistently sad, anxious or empty mood; feelings of hopelessness, pessimism, guilt, worthlessness, or helplessness; social withdrawal; unusual fatigue , low energy level, a feeling of being slowed down; sleep disturbance with insomnia, early-morning awakening, or oversleeping; trouble concentrating, remembering, or making decisions; unusual restlessness or irritability; persistent physical problems such as headaches, digestive disorders, or chronic pain that do not respond to treatment; thoughts of death or suicide or suicide attempts. Alcohol or drug abuse may be signs of depression.

Disabling episodes of major depression can occur once or a number of times in a lifetime.

For more information, see Depression .

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