MG myasthenia gravis (MG): An autoimmune neuromuscular disorder characterized by fatigue and exhaustion of muscles. It is caused by a mistaken immune response to the nicotinic acetylcholine receptors (AChR), which are found in junctions between muscles and the nervous system . The body produces antibodies that attack these AChR receptors, preventing signals from reaching the muscles. Proof that the anti-AChR antibodies are responsible for myasthenia comes from the effect these antibodies can have on the unborn and the newborn.

Pregnancy: During pregnancy in a woman with myasthenia, the anti-AChR antibodies can cross the placenta and block the function of the fetal form of AChR leading to fetal paralysis . Fetal and neonatal death is a common consequence. Babies who survive often have arthrogryposis multiplex congenita (nonprogressive congenital contractures) due to lack of fetal muscle movement before birth. Transient signs of MG are seen in 10-15% of babies born to MG mothers. These problems are potentially preventable if the mother is effectively treated during pregnancy.

Treatment: There is currently no cure for myasthenia gravis , but today at least 90 percent of patients with MG survive. A number of treatments are available that help, including steroids and other immunosuppressive medications and cholinergic medications.

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