Mononucleosis: Infection with the Epstein-Barr virus (EBV, human herpesvirus 4, HHV-4) in which there is an increase of white blood cells that have a single nucleus (monocytes). The infection can be spread by saliva. Its incubation period is four to eight weeks. Symptoms include fever , fatigue, sore throat , and swollen lymph glands. Mononucleosis can cause liver inflammation (hepatitis) and spleen enlargement; vigorous contact sports should be avoided to prevent spleen rupture. It is less severe in young children.

Most people exposed to EBV do not develop mononucleosis: most adults carry an antibody against EBV in their blood, meaning they have been infected with EBV at some time. Treatment includes rest, pain medication, and in some cases anti-viral medication.

Also known as mono, the kissing disease. See also Epstein-Barr virus.

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