Retinoic acid syndrome: A syndrome that occurs from treatment with retinoic acid and is characterized by fever , dyspnea (difficulty breathing), chest pain, lung infiltrates evident on chest X-ray , pleural and pericardial effusions (fluid around the lungs and heart ) and hypoxia (lack of oxygen ).

The syndrome occurs within the first 3 weeks of retinoic acid treatment, for example, with the drug ATRA (all-trans retinoic acid) used in treating APL acute promyelocytic leukemia ).

The retinoic acid syndrome involves the adhesion (sticking) of malignant cells in the pulmonary blood vessels. Steroids, chemotherapy , and supportive measures can help. The syndrome is a very serious complication. About 10% of patients with the syndrome die of it.

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