Sandhoff disease: A genetic disorder with symptoms that are very similar to those of Tay-Sachs disease (TSD) and that is characterized by accumulation of fatty material called GM2 ganglioside in the nerve cells of the brain. Symptoms begin around 6 months of age, with motor weakness, and progress to include difficulties with swallowing and breathing. Death usually occurs by age 3. Sandhoff disease is an autosomal recessive disorder caused by a mutation to chromosome 5. Unlike TSD, it is most common in the non-Jewish population. See also Tay-Sachs disease .
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