GENERIC NAME: aurothiomalate

BRAND NAME: Myochrysine

DRUG CLASS AND MECHANISM: Aurothiomalate is a gold salt used in treating inflammatory arthritis . Exactly how gold salts work is not well understood. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis , gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids).

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Injectable solution: 50mg/ml.

STORAGE: Store at room temperature, sealed container, avoid light.

PRESCRIBED FOR: Aurothiomalate is used in the treatment of active, progressive, or destructive forms of inflammatory arthritis, such as adult and juvenile rheumatoid arthritis.

DOSING: Should be given intramuscularly using sterile technique.

DRUG INTERACTIONS: Aurothiomalate should be avoided by patients with a history of serious reaction to any gold medication, including Solganal and Ridaura. Aurothiomalate should not be used with penicillamine (Depen, Cuprimine), another arthritis medication. It should also be avoided in patients with blood, liver or kidney diseases, recent radiation treatment, or uncontrolled diabetes. Patients should report to their practitioners any new rashes, itching, mouth sores, or unusual taste, while taking aurothiomalate. Gold is excreted slowly from the body. Safety and effectiveness in children less than six years of age has not been established.

PREGNANCY: Usage in pregnant or nursing mothers is generally avoided.

NURSING MOTHERS: It has been found in the breast milk of nursing mothers.

SIDE EFFECTS: Side effects of gold salts can occur any time during treatment or months after treatment has been discontinued. The most common adverse reaction to aurothiomalate is inflamed skin. An itching sensation can be an early warning sign of skin reaction (dermatitis). Aurothiomalate can cause grayish blue discoloration of the skin. It can also cause a metallic taste and mouth sores. Because gold salts can cause serious kidney and bone marrow problems, all patients require regular blood and urine test monitoring. An unusual side effect of injectable gold is flushing, dizziness , and fainting immediately after the injection. Patients starting injectable gold are observed after the first dose for this problem. Rarely, patients can have severe allergic reactions to aurothiomalate resulting in shock.

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