GENERIC NAME: guaifenesin

BRAND NAME: Humibid, Humibid LA, Robitussin, Organidin NR, Fenesin

DRUG CLASS AND MECHANISM: Guaifenesin is an expectorant, that is, a medication that promotes elimination of mucus from the lungs. The expectorant effects of guaifenesin promote elimination of mucous by thinning the mucous and lubricating the irritated respiratory tract. Guaifenesin is an ingredient in many over-the-counter cough and cold products. Guaifenesin was first approved by the FDA in 1952.

PRESCRIPTION: no

GENERIC AVAILABLE: yes

PREPARATIONS: Prescription forms include syrup (100 mg per teaspoonful); 200 mg tablets (200 Organidin NR); sustained release 300 mg capsules (Humibid); 600 mg sustained release tablets (Fenesin; Humibid LA). The only non-prescription form is a 600 mg extended release tablet (Mucinex).

STORAGE: Tablets, capsules, and syrup should be stored below 30°C (86°F). Do not refrigerate the liquid.

PRESCRIBED FOR: Guaifenesin is used for the treatment of cough associated with colds and minor upper respiratory tract infections.

DOSING: Guaifenesin may be taken with or without food. The sustained release tablets and capsules should be taken whole. They should not be broken or opened.

DRUG INTERACTIONS: There are no known drug interactions with guaifenesin.

PREGNANCY: Although one analysis found a correlation between guaifenesin use in the first trimester and an increased risk of hernia in the fetus, others found no increased risk of fetal malformations. Thus, guaifenesin should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential and unknown risks.

NURSING MOTHERS: It is not known if guaifenesin is secreted into breast milk.

SIDE EFFECTS: Side effects of guaifenesin are uncommon. In doses higher than those typically used, nausea, vomiting, diarrhea , abdominal pain, or drowsiness may occur.

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