GENERIC NAME: lisinopril

BRAND NAME: Zestril, Prinivil

DRUG CLASS AND MECHANISM: Lisinopril is an angiotensin converting enzyme (ACE) inhibitor. Angiotensin is a chemical that is made by the body continuously. It narrows blood vessels and thereby maintains (elevates) blood pressure. When the enzyme is blocked by lisinopril, angiotensin cannot be converted into its active form. As a result, blood pressure falls.

Interestingly, lisinopril and other ACE inhibitors were developed from the venom of a poisonous Brazilian snake.

PRESCRIPTION: yes

GENERIC AVAILABLE: yes

PREPARATIONS: 5mg, 10mg, 20mg, and 40mg oral tablets.

STORAGE: Lisinopril should be stored in a dry place at 15-30°C (59-86 °F).

PRESCRIBED FOR: Lisinopril is used to treat elevated blood pressure and heart failure.

DOSING: Lisinopril should be taken at doses specifically directed by the physician. Lisinopril can be taken with or without food. Lisinopril should be taken at the same time each day to maintain consistent blood levels. Lisinopril should not be taken within two hours of taking an antacid since the antacid binds lisinopril and prevents its absorption. Lisinopril is often tapered when discontinuing.

DRUG INTERACTIONS: First doses of lisinopril or any ACE inhibitor should be taken under observation if the patient also is taking diuretics (water pills). In such patients, blood pressure can drop quickly (though this is unusual).

PREGNANCY: Lisinopril should not be taken during pregnancy.

SIDE EFFECTS: First doses of lisinopril can cause dizziness due to a drop in blood pressure. Lisinopril should be stopped if there are symptoms or signs of an allergic reaction including feelings of swelling of the face, lips, tongue or throat. Severe allergic reactions ( anaphylaxis ) and hives occasionally occur.

An uncommon but dangerous side effect is a drop in the white blood cells which fight infection. Cough is a known side effect of this drug.

Lisinopril can impair the function of the kidneys, and every person taking this medication should have their kidney function checked. Lisinopril rarely can cause nausea, headaches, anxiety, insomnia, drowsiness, nasal congestion and sexual dysfunction.

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