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GENERIC NAME: nisoldipine

BRAND NAME: Sular

DRUG CLASS AND MECHANISM: Nisoldipine is an oral calcium-channel blocker (CCB) of the dihydropyridine (DHP) class. Other calcium channel blockers in the DHP class include nifedipine (Procardia, Adalat), amlodipine (Norvasc), felodipine (Plendil), nicardipine (Cardene), and isradipine (Dynacirc). Calcium-channel blockers prevent calcium from entering certain types of muscle cells. Since the muscle cells need calcium to contract, CCBs prevent the cells from contracting, that is, they cause the muscle cells to relax. Nisoldipine selectively relaxes the muscles of small arteries causing them to dilate but has little or no effect on muscles of the veins or the heart. Nisoldipine was approved by the FDA in February of 1995.

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Tablets: 10mg, 20mg, 30mg, 40mg.

STORAGE: Tablets should be stored below 30°C (86 °F) and should be protected from light and moisture.

PRESCRIBED FOR: Nisoldipine is used to treat high blood pressure. It may be used alone or in combination with other agents. Nisoldipine is also used to treat patients with angina and is being studied in patients with congestive heart failure .

DOSING: Most patients need between 20mg and 40mg once daily. Adults with advanced liver diseases or persons over the age of 65 years are often begun at a lower dose 10 mg), which may then be increased slowly for maximal effect. Some patients may benefit with doses of 60 mg/day. Others, especially those with angina, may need twice daily dosing.

DRUG INTERACTIONS: Cimetidine (Tagamet) can increase blood levels of nisoldipine, possibly causing more side effects.

PREGNANCY: The effects of nisoldipine in pregnancy are unknown.

NURSING MOTHERS: It is unknown if nisoldipine appears in breast milk.

SIDE EFFECTS: Peripheral edema (swollen ankles and feet) and headache are the most common side effects of nisoldipine. Dizziness may also occur.

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